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Rice大学David Yu Zhang教授访问我中心

发布时间:2015-06-03


  The Ted Law Jr. Assistant Professor of Rice Department of Bioengineering, Dr. David Yu Zhang, visited our institution and gave a presentation titled “Nucleic acid diagnostics based on hybridization” in Rm 329 on Apr. 29, 2015, which was hosted by Dr. Suling Liu.

  David Yu Zhang leads the Nucleic Acid Bioengineering Laboratory (NABLab) at Rice University's BioScience Research Collaborative. His investigations involve the systematic modeling and rational design of nucleic acids, such as DNA and RNA. Zhang is particularly interested in understanding how natural nucleic acids behave, and in the engineering of designer nucleic acid molecules that enable revolutionary in vitro diagnostics, in situ imaging, tissue engineering, transcription regulation, and materials scaffolding and modulation.

  In his lecture, Dr. Zhang introduced us the development of clinical diagnostic tools and devices based on analysis of circulated DNA and RNA. He mentioned that nucleic acids are signature molecules of life, and almost all diseases possess some nucleic acid component that could potentially be used as a biomarker. Specifically, recent research has shown that a surprisingly large (1000+) number of cancer-specific nucleic acid molecules exist in each mL of blood. His lab is developing ultraspecific and ultrasensitive enzyme-free methods of discriminating and amplification nucleic acid biomarkers. The development of reliable enzyme-free disease diagnostics could enable frequent non-invasive screens, such as for home or primary care use.